The SentinelOne Annual Threat Report - A Defenders Guide from the FrontlinesThe SentinelOne Annual Threat ReportGet the Report
Experiencing a Breach?Blog
Get StartedContact Us
SentinelOne
  • Platform
    Platform Overview
    • Singularity Platform
      Welcome to Integrated Enterprise Security
    • AI for Security
      Leading the Way in AI-Powered Security Solutions
    • Securing AI
      Accelerate AI Adoption with Secure AI Tools, Apps, and Agents.
    • How It Works
      The Singularity XDR Difference
    • Singularity Marketplace
      One-Click Integrations to Unlock the Power of XDR
    • Pricing & Packaging
      Comparisons and Guidance at a Glance
    Data & AI
    • Purple AI
      Accelerate SecOps with Generative AI
    • Singularity Hyperautomation
      Easily Automate Security Processes
    • AI-SIEM
      The AI SIEM for the Autonomous SOC
    • AI Data Pipelines
      Security Data Pipeline for AI SIEM and Data Optimization
    • Singularity Data Lake
      AI-Powered, Unified Data Lake
    • Singularity Data Lake for Log Analytics
      Seamlessly Ingest Data from On-Prem, Cloud or Hybrid Environments
    Endpoint Security
    • Singularity Endpoint
      Autonomous Prevention, Detection, and Response
    • Singularity XDR
      Native & Open Protection, Detection, and Response
    • Singularity RemoteOps Forensics
      Orchestrate Forensics at Scale
    • Singularity Threat Intelligence
      Comprehensive Adversary Intelligence
    • Singularity Vulnerability Management
      Application & OS Vulnerability Management
    • Singularity Identity
      Identity Threat Detection and Response
    Cloud Security
    • Singularity Cloud Security
      Block Attacks with an AI-Powered CNAPP
    • Singularity Cloud Native Security
      Secure Cloud and Development Resources
    • Singularity Cloud Workload Security
      Real-Time Cloud Workload Protection Platform
    • Singularity Cloud Data Security
      AI-Powered Threat Detection for Cloud Storage
    • Singularity Cloud Security Posture Management
      Detect and Remediate Cloud Misconfigurations
    Securing AI
    • Prompt Security
      Secure AI Tools Across Your Enterprise
  • Why SentinelOne?
    Why SentinelOne?
    • Why SentinelOne?
      Cybersecurity Built for What’s Next
    • Our Customers
      Trusted by the World’s Leading Enterprises
    • Industry Recognition
      Tested and Proven by the Experts
    • About Us
      The Industry Leader in Autonomous Cybersecurity
    Compare SentinelOne
    • Arctic Wolf
    • Broadcom
    • CrowdStrike
    • Cybereason
    • Microsoft
    • Palo Alto Networks
    • Sophos
    • Splunk
    • Trellix
    • Trend Micro
    • Wiz
    Verticals
    • Energy
    • Federal Government
    • Finance
    • Healthcare
    • Higher Education
    • K-12 Education
    • Manufacturing
    • Retail
    • State and Local Government
  • Services
    Managed Services
    • Managed Services Overview
      Wayfinder Threat Detection & Response
    • Threat Hunting
      World-Class Expertise and Threat Intelligence
    • Managed Detection & Response
      24/7/365 Expert MDR Across Your Entire Environment
    • Incident Readiness & Response
      DFIR, Breach Readiness, & Compromise Assessments
    Support, Deployment, & Health
    • Technical Account Management
      Customer Success with Personalized Service
    • SentinelOne GO
      Guided Onboarding & Deployment Advisory
    • SentinelOne University
      Live and On-Demand Training
    • Services Overview
      Comprehensive Solutions for Seamless Security Operations
    • SentinelOne Community
      Community Login
  • Partners
    Our Network
    • MSSP Partners
      Succeed Faster with SentinelOne
    • Singularity Marketplace
      Extend the Power of S1 Technology
    • Cyber Risk Partners
      Enlist Pro Response and Advisory Teams
    • Technology Alliances
      Integrated, Enterprise-Scale Solutions
    • SentinelOne for AWS
      Hosted in AWS Regions Around the World
    • Channel Partners
      Deliver the Right Solutions, Together
    • SentinelOne for Google Cloud
      Unified, Autonomous Security Giving Defenders the Advantage at Global Scale
    • Partner Locator
      Your Go-to Source for Our Top Partners in Your Region
    Partner Portal→
  • Resources
    Resource Center
    • Case Studies
    • Data Sheets
    • eBooks
    • Reports
    • Videos
    • Webinars
    • Whitepapers
    • Events
    View All Resources→
    Blog
    • Feature Spotlight
    • For CISO/CIO
    • From the Front Lines
    • Identity
    • Cloud
    • macOS
    • SentinelOne Blog
    Blog→
    Tech Resources
    • SentinelLABS
    • Ransomware Anthology
    • Cybersecurity 101
  • About
    About SentinelOne
    • About SentinelOne
      The Industry Leader in Cybersecurity
    • Investor Relations
      Financial Information & Events
    • SentinelLABS
      Threat Research for the Modern Threat Hunter
    • Careers
      The Latest Job Opportunities
    • Press & News
      Company Announcements
    • Cybersecurity Blog
      The Latest Cybersecurity Threats, News, & More
    • FAQ
      Get Answers to Our Most Frequently Asked Questions
    • DataSet
      The Live Data Platform
    • S Foundation
      Securing a Safer Future for All
    • S Ventures
      Investing in the Next Generation of Security, Data and AI
  • Pricing
Get StartedContact Us
CVE Vulnerability Database
Vulnerability Database/CVE-2021-28449

CVE-2021-28449: Microsoft 365 Apps RCE Vulnerability

CVE-2021-28449 is a remote code execution vulnerability in Microsoft 365 Apps that allows attackers to execute arbitrary code. This article covers the technical details, affected versions, security impact, and mitigation.

Published: February 25, 2026

CVE-2021-28449 Overview

CVE-2021-28449 is a Remote Code Execution vulnerability affecting Microsoft Office products. This vulnerability allows an attacker to execute arbitrary code on a target system when a user opens a specially crafted Office document. The attack requires user interaction, as the victim must open a malicious file, but successful exploitation can lead to complete system compromise with the same privileges as the current user.

Critical Impact

Successful exploitation allows attackers to execute arbitrary code with user privileges, potentially leading to full system compromise, data theft, or lateral movement within enterprise networks.

Affected Products

  • Microsoft 365 Apps (Enterprise)
  • Microsoft Excel 2010 SP2, 2013 SP1, 2016
  • Microsoft Office 2010 SP2, 2013 SP1, 2016, 2019

Discovery Timeline

  • April 13, 2021 - CVE-2021-28449 published to NVD
  • November 21, 2024 - Last updated in NVD database

Technical Details for CVE-2021-28449

Vulnerability Analysis

This Remote Code Execution vulnerability exists in the way Microsoft Office products handle certain objects in memory when processing Office documents. The vulnerability can be triggered when a user opens a specially crafted document that contains malicious content designed to exploit the flaw in Office's document parsing functionality.

The attack vector is local, meaning an attacker must convince a user to open a malicious file delivered through phishing emails, compromised websites, or file-sharing services. Once the document is opened, the exploit can execute arbitrary code in the context of the current user. If the user has administrative privileges, the attacker could gain complete control over the affected system.

The vulnerability affects multiple versions of Microsoft Office spanning from Office 2010 SP2 through Microsoft 365 Apps for Enterprise, representing a significant attack surface across enterprise environments that may still be running legacy Office versions.

Root Cause

The vulnerability stems from improper handling of objects in memory within Microsoft Office components. While specific technical details have not been publicly disclosed by Microsoft, this class of vulnerability typically involves memory corruption issues during document parsing operations. The flaw allows maliciously crafted content within Office documents to corrupt memory in a way that can be leveraged for code execution.

Attack Vector

The attack requires local interaction where a victim opens a malicious Office document. Attack scenarios include:

  1. Phishing campaigns - Attackers send emails with malicious Office documents attached, using social engineering to convince recipients to open them
  2. Watering hole attacks - Malicious documents hosted on compromised websites that users are likely to visit
  3. Supply chain compromise - Malicious documents embedded in legitimate-looking business communications or shared through collaboration platforms

The attacker does not need any privileges on the target system to exploit this vulnerability, but user interaction is required. The vulnerability cannot be exploited remotely without user action.

Detection Methods for CVE-2021-28449

Indicators of Compromise

  • Suspicious Office processes spawning unexpected child processes (e.g., cmd.exe, powershell.exe, mshta.exe)
  • Office applications making unusual network connections immediately after opening documents
  • Anomalous memory allocation patterns in Office process space
  • Creation of unexpected files in temporary directories following document opening

Detection Strategies

  • Monitor for Office applications spawning shell processes or script interpreters
  • Implement behavioral analysis rules for Office process trees that deviate from normal patterns
  • Deploy endpoint detection rules that alert on suspicious Office document execution chains
  • Analyze Office documents in sandboxed environments before allowing user access

Monitoring Recommendations

  • Enable detailed logging for Office application events and process creation
  • Monitor network traffic from Office applications for unusual outbound connections
  • Implement file integrity monitoring on critical system directories
  • Configure security information and event management (SIEM) rules for Office-related exploitation patterns

How to Mitigate CVE-2021-28449

Immediate Actions Required

  • Apply the Microsoft security update from the April 2021 Patch Tuesday release immediately
  • Enable Protected View for Office documents from untrusted sources
  • Configure attack surface reduction rules in Microsoft Defender for Endpoint
  • Educate users about the risks of opening Office documents from unknown sources

Patch Information

Microsoft has released security updates to address this vulnerability as part of the April 2021 security updates. Patches are available for all affected products including Microsoft Office 2010 SP2, 2013 SP1, 2016, 2019, and Microsoft 365 Apps for Enterprise. For detailed patch information and download links, refer to the Microsoft Security Advisory for CVE-2021-28449.

Organizations should prioritize patching based on the criticality of systems and exposure to external document sources. Legacy Office versions (2010, 2013) should be considered for upgrade to supported versions to ensure continued security updates.

Workarounds

  • Configure Microsoft Office to open documents in Protected View by default
  • Implement Office Document Trusted Locations policies to restrict which locations can bypass security features
  • Use Application Guard for Office to isolate potentially malicious documents
  • Deploy email filtering solutions to block suspicious Office attachments before delivery to end users
bash
# PowerShell: Enable Protected View via Registry for all Office applications
# Run in elevated PowerShell session
$OfficeVersions = @("16.0", "15.0", "14.0")
$OfficeApps = @("Excel", "Word", "PowerPoint")

foreach ($version in $OfficeVersions) {
    foreach ($app in $OfficeApps) {
        $regPath = "HKCU:\Software\Microsoft\Office\$version\$app\Security\ProtectedView"
        if (-not (Test-Path $regPath)) {
            New-Item -Path $regPath -Force | Out-Null
        }
        Set-ItemProperty -Path $regPath -Name "DisableInternetFilesInPV" -Value 0 -Type DWord
        Set-ItemProperty -Path $regPath -Name "DisableAttachmentsInPV" -Value 0 -Type DWord
        Set-ItemProperty -Path $regPath -Name "DisableUnsafeLocationsInPV" -Value 0 -Type DWord
    }
}
Write-Host "Protected View settings configured for all Office applications"

Disclaimer: This content was generated using AI. While we strive for accuracy, please verify critical information with official sources.

  • Vulnerability Details
  • TypeRCE

  • Vendor/TechMicrosoft

  • SeverityHIGH

  • CVSS Score7.8

  • EPSS Probability8.36%

  • Known ExploitedNo
  • CVSS Vector
  • CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H
  • Impact Assessment
  • ConfidentialityLow
  • IntegrityHigh
  • AvailabilityHigh
  • CWE References
  • NVD-CWE-noinfo
  • Vendor Resources
  • Microsoft Security Advisory CVE-2021-28449
  • Related CVEs
  • CVE-2026-32191: Microsoft Bing Images RCE Vulnerability

  • CVE-2026-21536: Microsoft Devices Pricing RCE Vulnerability

  • CVE-2026-27848: MR9600/MX4200 RCE Vulnerability

  • CVE-2021-24105: Package Manager Configurations RCE Flaw
Default Legacy - Prefooter | Experience the World’s Most Advanced Cybersecurity Platform

Experience the World’s Most Advanced Cybersecurity Platform

See how our intelligent, autonomous cybersecurity platform can protect your organization now and into the future.

Try SentinelOne
  • Get Started
  • Get a Demo
  • Product Tour
  • Why SentinelOne
  • Pricing & Packaging
  • FAQ
  • Contact
  • Contact Us
  • Customer Support
  • SentinelOne Status
  • Language
  • Platform
  • Singularity Platform
  • Singularity Endpoint
  • Singularity Cloud
  • Singularity AI-SIEM
  • Singularity Identity
  • Singularity Marketplace
  • Purple AI
  • Services
  • Wayfinder TDR
  • SentinelOne GO
  • Technical Account Management
  • Support Services
  • Verticals
  • Energy
  • Federal Government
  • Finance
  • Healthcare
  • Higher Education
  • K-12 Education
  • Manufacturing
  • Retail
  • State and Local Government
  • Cybersecurity for SMB
  • Resources
  • Blog
  • Labs
  • Case Studies
  • Videos
  • Product Tours
  • Events
  • Cybersecurity 101
  • eBooks
  • Webinars
  • Whitepapers
  • Press
  • News
  • Ransomware Anthology
  • Company
  • About Us
  • Our Customers
  • Careers
  • Partners
  • Legal & Compliance
  • Security & Compliance
  • Investor Relations
  • S Foundation
  • S Ventures

©2026 SentinelOne, All Rights Reserved.

Privacy Notice Terms of Use

English